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Conquer Cancer-Funded Researcher Dr. David Margel’s BRCA Study, Clinic Are Saving Men’s Lives in Israel

Sep 02, 2020

Uriya, age 49, visits Israel’s Rabin Medical Center for a cancer screening. On the surface, he shows no signs of disease. However, results from a study by David Margel, MD, PhD, reveal Uriya is living with prostate cancer at an early, yet curable, stage. Uriya carries the BRCA gene. Rabin Medical Center, founded and led by Dr. Margel, is dedicated to caring for male BRCA carriers; Dr. Margel’s research is supported by a Career Development Award (CDA) from Conquer Cancer, the ASCO Foundation.

While the effects of BRCA gene mutations on women are well known, the risks for men are often overlooked. Male carriers face heightened risk of developing an aggressive form of prostate cancer at an early age.

“Even within the BRCA community, men are treated as ‘carrying vectors’ rather than patients who need care,” Dr. Margel explained. “Before coming to our clinic, Uriya constantly feared he would succumb to cancer, similar to his father and other family members.”

“I knew that I was at risk,” Uriya said. “But no one offered guidance.”

Dr. Margel found that for male BRCA carriers, standard screenings and regular physicals may not be enough to adequately detect the disease. “MRI can detect many more cancer cases. We are now adjusting our screening guidelines for prostate cancer in BRCA carriers,” he said.

Further studies are needed to better treat at-risk populations underrepresented in clinical trials. Donors make a tangible difference in the research needed to help patients like Uriya detect and conquer cancer before it grows and spreads.

“Funding from the CDA helped me establish and hire my research team, which now includes a PhD in molecular biology and three research assistants,” Dr. Margel said. “I was also able to establish the male BRCA clinic and create a one-of-a-kind bio-bank with over 4,000 samples from BRCA carriers.”

“Before, I was lost,” Uriya told Dr. Margel. “After joining your clinic, I gained back control.”

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