Participant Instructions: Welcome to the Multidisiplinary Molecular Oncology Tumor Board Series! This educational initiative is a collaboration between the American Society of Clinical Oncology (ASCO), College of American Pathologists (CAP), and Association for Molecular Pathology (AMP).
A new case will be presented bi-monthly with discussions led by an expert pathologist and medical oncologist. This month’s topic is led by Drs. Jason Westin (Hematologist/Oncologist from MD Anderson) and Alexandra Kovach (Hematopathologist from Vanderbilt).
Do you have an interesting case in mind? Submit your hypothetical patient cases for consideration in an upcoming Multidisciplinary Molecular Tumor Board discussion forum.
Participants are encouraged to leave comments and post questions about the case in order to generate a wide discussion among the cancer care community. You can also receive email notifications when new comments are posted by clicking the “Follow this Conversation” option located at the bottom of this page.
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Patient Case
A 62-year-old woman with history of hypertension and monoclonal B-cell lymphocytosis (MBL) presents to your clinic with asymptomatic cervical, supraclavicular and inguinal lymphadenopathy. Her ECOG performance status is 0, and her LDH is elevated at 675 U/L (upper limit of normal 225). Excisional lymph node biopsy is performed. A preliminary pathology report gives a diagnosis of large B-cell lymphoma, pending FISH studies for final WHO subclassification. The final pathology diagnosis returns as high-grade B-cell lymphoma not otherwise specified (HGBCL-NOS). Bone marrow biopsy is negative for HGBCL-NOS; flow cytometry of bone marrow aspirate material detects the patient’s known MBL. PET/CT shows additional widespread hilar, mediastinal, and retroperitoneal lymphadenopathy.