Answering Your Patients’ Question: “What did you learn at the Meeting?”

Answering Your Patients’ Question: “What did you learn at the Meeting?”

Yousuf Zafar, MD, MHS

@yzafar
Jun 06, 2013

“So what did you learn at the meeting? Is there something new for me?” Sometime during my first clinic session after the ASCO Annual Meeting, I inevitably get asked these questions by patients. It’s gotten so common that I expect the questions and prepare an answer. Usually, I’m asked these questions by patients with the most advanced cancers. So what do I want to say? I want to say: “I saw some pretty amazing preliminary data on drugs that aren’t ready for prime time, yet”; or, “There’s jaw-dropping work being done with decision-support tools in cancer”; or, “There was this inspiring study on screening for cervical cancer in India. . . .”

But that’s not what patients want to hear. There’s often an expectation that at national meetings—along with abstracts—vials of new, blockbuster drugs are handed out like shampoo samples. We pack them in our bags and rush home to infuse them into patients. I wish that was the case. Instead, we hear updates on combinations promising in phase II, but not so promising in phase III. We hear partial data on encouraging interventions, but wait months for full publication and even longer for regulatory approval. Realistically, what we bring home from meetings is not a vial of “cureximab,” but a hopeful wait-and-see attitude.

But that’s not so helpful for our patients anticipating the next best therapy, waiting for a spot in an early-phase clinical trial. They need something much sooner, and rarely do data-packed meetings provide an immediate answer for them. In occasional instances, meetings can have a fairly rapid impact on practice, where new drugs are disseminated into practice before publication in high-impact journals. But on the other hand, practice-changing data presented at meetings can lie suspended in abstract form for years before being published—or, worse, can never be published at all. The pace of cancer drug development has quickened, at least in isolated cases, but it must go faster. A path to faster drug discovery and development depends on: better funding of biomedical research; development of stronger industry/academic/community partnerships for development; improving the evaluation process; streamlining post-approval monitoring; and more. Work needs to be done to ensure meeting abstracts see the light of day in publications—whether findings were positive or negative. We owe it to the patients who participated in the studies and the patients expecting results.

Returning home from the ASCO Annual Meeting, I’m rejuvenated by new collaborations, stimulating research questions, and exciting data. I can predict how cancer treatment a year from now will be different from cancer treatment today. But how do I relate this trend to patients who need more treatment options now? A patient who had just participated in a phase I trial asked me, “So, anything new for me at the oncology meeting this year?” I responded, “There are some very exciting treatments around the corner. We are making progress everyday, and by participating in a trial, you have contributed to that process.” I wish I had a better answer. How do you answer this question?

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Comments

Michael Jordan Fisch, MD, MPH, FASCO

Jun, 08 2013 6:29 PM

Yousuf, your experience post-ASCO absolutely resonates with me.  I feel a bit guilty, as I sometimes make general reference to progress in cancer care by saying things like "every year, thousands of cancer researchers all over the world assemble at the ASCO Annual Meeting and discuss the latest ideas and advances.."  I say that sort of thing to inspire hope, but it can lead to some unrealistic expectations about the immediate post-ASCO deliverables, as you pointed out very well.

I really like the response you offered to your patient who generously enrolled in a phase I trial: “There are some very exciting treatments around the corner. We are making progress everyday, and by participating in a trial, you have contributed to that process.” That statement is truthful, hopeful, and embodies that "generosity of spirit" that Dr. Theresa Gilewski alluded to referring to what should occur in the reciprocal interaction between the patient and physician.  In the ASCO session called "Beyond the Science of Illness:  The Personal Impact of Patient Care on Physicians", Dr. Gilewski talked about the "reciprocal interaction between human beings" that occurs during these encounters, about how difficult it is for us as physicians to be vulnerable, and how there is a continuous opportunity in medicine to learn not just about the science but also about humanity.  Thanks again, Yousuf, for your stimulating post-ASCO reflection.

Yousuf Zafar, MD, MHS

Jun, 10 2013 10:05 PM

Mike, thanks for your comment, and I'm glad to hear this resonates with you. Great point about using a difficult encounter like this to connect and learn about humanity. Ours is a unique profession, isn't it?

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