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1/19/2012 9:13 AM
 
  1. What is the role of neoadjuvant intensity modulated radiation therapy (IMRT) for localized rectal cancer?
  2. What is the optimal time between the completion of radiation therapy and surgery?

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1/28/2012 7:33 PM
 
I don't know the role of IMRT, but it is worthy of study, especially since the long term effects of chemotherapy and radiation therapy to the rectal bed endured by rectal cancer survivors are substantial.  Perhaps the place to start would be phase I/II IMRT with RT with concurrent capecitabine.  Although cape is said to be equal to 5FU in the R-04 study, the p value was 0.12 and cape might be better if the trial had more power.  From my experience, waiting longer is better; 8 or even 10 weeks is good, but I have no data for it.
 
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2/11/2012 12:17 AM
 
IMRT offer potential to reduce toxicity to the bowel,bladder but these is no set consensus .al so may spare iliac crest. RTOG has
publishing consensus contouring atlas to help standardize treatment.
IMRT in low rectal cancer is used to decrease dose to the genilalia
 
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